解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311430701
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pregnancies in women with systemic lupus erythematosus (SLE) and lupus nephritis are considered high-risk due to high rates of maternal and fetal complications. However, there has not been a formal analysis addressing the issue of maternal deaths in these women. The aim of this study was to pe...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311434939
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the occurrence of idiopathic intracranial hypertension (IIH) in patients with systemic lupus erythematosus (SLE) and to describe the manifestations, treatments and outcomes in these patients. METHODS:We reviewed the medical records of 1084 patients with SLE followed up from January 1997 to June 2...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311435267
更新日期:2012-04-01 00:00:00
abstract::Fatigue is one of the most complex and ill understood symptoms of chronic illness often reported as the number one complaint by patients with systemic lupus erythematosus (SLE). This paper aims to provide a comprehensive review of the literature on fatigue in SLE. A pool of 55 relevant articles was retrieved via elect...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203312436863
更新日期:2012-04-01 00:00:00
abstract::A 22-year-old female with history of systemic lupus erythematosus (SLE) was referred for evaluation of decreased visual acuity in her right eye. Her best-corrected visual acuity (BCVA) at the time of presentation was 20/160. Widespread cotton wool spots and macular edema were seen on biomicroscopy. Fluorescein angiogr...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311422095
更新日期:2012-03-01 00:00:00
abstract::Vaccines have undoubtedly brought overwhelming benefits to mankind and are considered safe and effective. Nevertheless, they can occasionally stimulate autoantibody production or even a recently defined syndrome known as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). There is scarce data regarding autoi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311429817
更新日期:2012-02-01 00:00:00
abstract::Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin D receptor) gene polymorphism was associated with SLE in Asian patients. Studies in Brazilian populations have not been realized. A case-control study with 195 SLE patients and 201 healthy controls was conducted to investi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311421798
更新日期:2012-01-01 00:00:00
abstract::In this study, we report the case of a Chinese patient with systemic lupus erythematosus (SLE) who developed neutropenia after treatment by olanzapine for the SLE-related psychiatric symptoms. The relationship between agranulocytosis, SLE and olanzapine is still unknown. Fcγ receptor IIIb (FcγRIIIb) is a low-affinity ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311415889
更新日期:2012-01-01 00:00:00
abstract::Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE). Cases complicated with DAH often have active SLE with multi-organ involvement, especially lupus nephritis. We describe a rare case of DAH as the first presenting manifestation of SLE in the absence of lupus neph...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311411353
更新日期:2011-12-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent thrombotic events, miscarriages and thrombocytopenia with persistently positive antiphospholipid antibodies.( 1,2 ) APS may be isolated (primary APS) or associated to a connective tissue disease, most often systemic lupus erythematosus...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311405373
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311405374
更新日期:2011-10-01 00:00:00
abstract::We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of ≥1 : 160, and the ratio of pleural effusion to serum ANA of ≥1, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of 54 patients with pleural eff...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311402531
更新日期:2011-10-01 00:00:00
abstract::We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311398510
更新日期:2011-10-01 00:00:00
abstract::Intestinal pseudo-obstruction (IpsO) occurs in a small subgroup of patients with systemic lupus erythematosus (SLE), and has been under-recognized. The etiology and mechanisms are unclear. Herein, we report two cases. In case 1, IpsO occurred as the complication in a previously diagnosed SLE patient. In case 2, IpsO w...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311405702
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311411598
更新日期:2011-10-01 00:00:00
abstract::A 7-year-old boy presented with adrenal insufficiency. He subsequently developed venous thrombosis in the limbs and was diagnosed with primary antiphospholipid syndrome (PAPS) based on clinical and laboratory parameters. Both adrenals were normal on imaging. He required thrombolysis and anticoagulation. The progressiv...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203310397965
更新日期:2011-10-01 00:00:00
abstract::Therapeutic agents currently in use to treat systemic lupus erythematosus (SLE) are predominantly immunosuppressive agents with limited specificities. Multiple groups, including ours, have illustrated that inducing tolerance in SLE animal models ameliorates disease symptoms and increases survival. We examined if oral ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311398509
更新日期:2011-08-01 00:00:00
abstract::High levels of serum and/or plasma circulating DNA (cDNA) have been described in patients with systemic autoimmune diseases (SADs). However, the role of this molecule has not been clarified. Our aim was to evaluate plasma cDNA levels in 48 systemic lupus erythematosus (SLE) and 44 primary Sjögren's syndrome (SS) patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311399606
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Cardiomyopathy in systemic lupus erythematosus (SLE) may be secondary to myocardial inflammation (i.e. myocarditis) or to systemic complications such as hypertension. Symptomatic left ventricular dysfunction is the most common clinical presentation of cardiomyopathy and is potentially life threatening. Ident...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310395800
更新日期:2011-08-01 00:00:00
abstract::Consanguineous marriage is quite prevalent in the Sultanate of Oman, with up to 45% of marriages being consanguineous. The aim of this study was to determine demographic, clinical and serological characteristics between familial and non-familial cases of juvenile systemic lupus erythematosus (SLE) in a highly consangu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310383299
更新日期:2011-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies and complement activation. Recent studies have suggested that anti-nuclear antibody (ANA) positivity may disappear over time in some SLE patients. Anti-double-stranded DNA (dsDNA) antibody titers and complement levels may vary with time and...
journal_title:Lupus
pub_type: 历史文章,杂志文章
doi:10.1177/0961203310385738
更新日期:2011-03-01 00:00:00
abstract::Dysregulated neutrophil apoptosis may result in the development of autoimmune disease by contributing to nuclear autoantigen exposure, leading to autoantibody generation and a breakdown in immune tolerance. It has previously been shown that neutrophil apoptosis is increased in juvenile-onset systemic lupus erythematos...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310382128
更新日期:2011-01-01 00:00:00
abstract::We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had fail...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/0961203310366573
更新日期:2010-07-01 00:00:00
abstract::Gamma-aminobutyric acid-A (GABA-A) receptors play a crucial role in regulating neuronal excitability and cognitive functions. Single-photon emission computerized tomography (SPECT) analysis of GABA-A receptors binding by (123)I-labelled Iomazenil ((123)I-IMZ) has been applied in some neuropsychiatric disorders to inve...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310364398
更新日期:2010-07-01 00:00:00
abstract::Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309359780
更新日期:2010-06-01 00:00:00
abstract::Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310361350
更新日期:2010-06-01 00:00:00
abstract::Abnormalities of the lipid profile partly explain the atherogenic tendency of systemic lupus erythematosus but the picture is unclear in thrombotic primary antiphospholipid syndrome (PAPS). Herein we compare the lipid profile, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (CHO), apol...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309357765
更新日期:2010-05-01 00:00:00
abstract::The objective of this article was to evaluate whether serum uric acid (SUA) correlates with arterial stiffness and inflammation markers in a cohort of women with systemic lupus erythematosus (SLE) without overt atherosclerotic cardiovascular diseases, who attended a community hospital. One hundred and two women with S...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309355301
更新日期:2010-04-01 00:00:00
abstract::Systemic lupus erythematosus may present with renal manifestations that frequently are difficult to categorize and lupus nephritis is an important predictor of poor outcome. The type and spectrum of renal injury may remain undiagnosed until full-blown nephritic and/or nephrotic syndrome appear with increased risk of e...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203309358187
更新日期:2010-04-01 00:00:00
abstract::Intravenous immunoglobulin (IVIG) has a therapeutic potential in many autoimmune diseases. Based on its immune modulating and complement inhibiting effects, IVIG has been tested in systemic lupus erythematosus (SLE), but due to osmotic tubular injury caused by immunoglobulin-stabilizing sugar components, lupus nephrit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309355299
更新日期:2010-04-01 00:00:00
abstract::Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360809
更新日期:2010-04-01 00:00:00
abstract::Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360541
更新日期:2010-04-01 00:00:00
abstract::Thrombosis in the presence of persistently positive tests for antiphospholipid antibodies is termed thrombotic antiphospholipid syndrome (APS). At present, 'standard' secondary thromboprophylaxis in thrombotic APS is treatment with moderate intensity oral anticoagulants for life after a first venous thrombosis and wit...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203309361483
更新日期:2010-04-01 00:00:00
abstract::This study was designed to investigate whether Foxp3( +) regulatory T (Treg) cells play a role in the histopathologic changes of primary Sjögren's Syndrome (pSS) and to evaluate other factors possibly associated with Foxp3(+) Treg cells in pSS patients. The number of FoxP3-expressing T cells in peripheral blood (PB) o...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309348234
更新日期:2010-02-01 00:00:00
abstract::Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345742
更新日期:2010-01-01 00:00:00
abstract::The aim of our study was to determine whether the SLEDAI-2K calculated using a timeframe of 30 days prior to a visit for clinical and laboratory variables was equivalent to the prescribed 10-day period. One hundred forty nine consecutive lupus patients seen over 9 weeks at the University of Toronto Lupus Clinic enroll...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309346505
更新日期:2010-01-01 00:00:00
abstract::The objective of this study was to determine the vitamin D status and its relationship with disease and therapy features and with bone mineral density in women with systemic lupus erythematosus. Non-pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D measurements performed b...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345775
更新日期:2010-01-01 00:00:00
abstract::Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345753
更新日期:2009-12-01 00:00:00
abstract::XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345777
更新日期:2009-12-01 00:00:00
abstract::Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203309345735
更新日期:2009-11-01 00:00:00